Our main goal is to understand how acquired brain injury leads to deficits in consciousness and high order cognitive functions and develop mechanistically informed solutions for diagnosis, prognostication, and improving outcomes. We use techniques such as MRI (structural and functional), non invasive brain stimulation, and behavioural approaches in both healthy volunteers and patients with acquired brain injury across the severity spectrum (from complex disorders of consciousness -DOC- to mild-traumatic brain injury -mTBI-) to test hypotheses about the role of different brain structures in the clinical deficits they present. Our research is directly translated into the development of diagnostic and prognostic biomarkers to be used in clinical settings, as well as the development of novel treatment approaches.